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KMID : 1134820120410030345
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 3 p.345 ~ p.350
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Effect of Cynanchi wilfordii Radix Extracts on Lipid Compositions and Blood Pressure in Spontaneously Hypertensive Rats
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Choi Jun-Hyeok
Lee Hye-Sung
Kim Young-Eon
Kim Byoung-Mok
Kim In-Ho
Lee Chang-Ho
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Abstract
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The purpose of this study was to observe the effects of Cynanchi wilfordii Radix extracts (CRE) on the improvement of the lipid compositions and blood pressure level in spontaneously hypertensive rats (SHR) fed an experimental diet for 5 weeks. The rats were divided into 3 groups: a control group, a 0.5% CRE treated group, and a 1% CRE treated group. Consumption of CRE extract for 5 weeks in SHR significantly suppressed blood pressure rise with aging (p<0.05). After eating the experimental diets, the triglycerides in serum was significantly lower in the CRE group than that in the control group. The fasting glucose levels of the 0.5% and 1% CRE group had a tendency to be lower compared with those of the control group. Total cholesterol, HDL-cholesterol and HTR (HDL-cholesterol/total cholesterol) of the SHR in the 0.5% and 1% CRE diet were significantly increased compared to the control diet. Thus, long term consumption of CRE might be beneficial in lowering high blood pressure and the improvement of lipid metabolism in SHR rats.
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KEYWORD
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Cynanchi wilfordii Radix, spontaneously hypertensive rat, cholesterol, triglyceride, blood pressure
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